Last data update: May 06, 2024. (Total: 46732 publications since 2009)
Records 1-2 (of 2 Records) |
Query Trace: Ngac PK[original query] |
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Mouth level intake of nicotine from three brands of little filtered cigars with widely differing product characteristics among adult consumers
Ashley DL , Zhu W , Watson CH , Bravo R , Ngac PK , Valentin-Blasini L , Pickworth WB , Kurti AN , Cunningham C , Blount BC . Chem Res Toxicol 2023 36 (1) 43-52 Little filtered cigars are tobacco products with many cigarette-like characteristics. However, despite cigars falling under the U.S. Food and Drug Administration regulatory authority, characterizing flavors, which are still allowed in little filtered cigars, and filter design may influence how people use the products and the resulting exposure to harmful and potentially harmful constituents. We estimated nicotine mouth level intake (MLI) from analyses of little cigar filter butt solanesol levels, brand characteristics, carbon monoxide boost, and puff volume in 48 dual cigarette/cigar users during two repeat bouts of ad lib smoking of three little filtered cigar brands. Mean nicotine MLI for the three brands was significantly different with Swisher Sweets (0.1% ventilation) Cherry at 1.20 mg nicotine, Cheyenne Menthol (1.5%) at 0.63 mg, and Santa Fe unflavored (49%) at 0.94 mg. The association between nicotine MLI and puff volume was the same between Cheyenne Menthol and Santa Fe unflavored. However, these were different from Swisher Sweets Cherry. At least five main factors─flavor, ventilation, filter design, nicotine delivery related to tar, and user puff volume─may directly or indirectly impact MLI and its association with other measures. We found that users of little filtered cigars that have different filter ventilation and flavor draw dissimilar amounts of nicotine from the product, which may be accompanied by differences in exposure to other harmful smoke constituents. |
First things first: a step in the right direction for the preanalytical phase of thiamine measurements
Pfeiffer CM , Fazili Z , Mineva EM , Ngac PK . Am J Clin Nutr 2021 114 (3) 829-830 The 2018 roadmap for global control programs for thiamine deficiency disorders calls out the lack of biochemical population data on thiamine status (1). This report states that “urgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences.” This situation poses a bit of a chicken and egg dilemma, as investigators need suitable analytical methods to produce high-quality biomarker data and policymakers need comparable and interpretable biomarker data to develop policies and evaluate their impact. Furthermore, analytical methods need to be paired with practical preanalytical conditions that allow for the collection and generation of valid biological specimens. For years, the field of thiamine research has been hampered due to the labile physiochemical properties of thiamine compounds and the lack of simple, yet reliable, analytical methods. |
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